| 高瑜 |
| 所属地区 |
中国 |
|
| 所属行业 |
未知 |
| 所属专业 |
未知 |
| 所属分类 |
高等院校 |
| 个人基本信息 |
| 性别 |
女 |
出生年月 |
未知 |
| 职称 |
副教授 |
学历 |
博士 |
| 研究领域 |
抗肿瘤转移纳米药物输送系统 |
| 毕业院校 |
中国科学院上海药物研究所 |
| 工作单位 |
福州大学化学学院 |
| 个人简介 |
专 业： 药剂学 电子邮件： hellogaoyu@ 研究方向： 抗肿瘤转移纳米药物输送系统 教育工作经历 教育背景 ☆ 2005.09–2010.07 中国科学院上海药物研究所 博士 专业：药剂学 ☆ 2001.09–2005.07 福州大学 学士 专业：制药工程 工作经历 ☆ 2010.07–2011.10 中国科学院上海药物研究所 助理研究员 ☆ 2013.03–至今 福州大学 副教授 教学简介 研究生课程：《现代药剂学》、《新药研发的跨学科知识和技能》
本科生课程：《综合化学实验》、《仪器分析实验》 助教课程：《无机和分析化学》、《仪器分析》 科研简介 主要从事创新药物制剂的研究，以提高药物的有效性、降低毒副作用。
主要学术成绩涵盖药物新材料、新技术和新工艺的应用基础研究：（1）成功构建多种新型靶向纳米载药系统改善难溶性药物的功效，降低毒副作用；（2）设计并合成出一系列新型基因非病毒载体显著提高基因药物转染效率；（3）构建多种纳米载药系统用于改善临床肿瘤治疗效果并进行详细机制研究；（4）设计构建可特异性调控循环肿瘤细胞用于预防肿瘤转移的纳米药物。以上学术成就已在国际重要学术期刊Biotechnol Adv、Drug Discov Today、ACS Nano、Biomaterials、J Controlled Release、Mol Pharmaceutics等上发表论文30余篇，第一作者19篇，累计影响因子达176.75分，论文已被引用527次，其中影响因子5.0以上的论文19篇，有17篇论文刊登在《SCI?JCR期刊综合评价主题分区表》一区期刊。相关成果申请专利7项，已授权3项。
主持国家自然科学基金青年项目1项，参与国家自然科学基金面上项目、“973”项目及国家重大新药创制项目等；获得上海市药学科技一等奖（2013，排名第五）、上海市药学科技一等奖（2009，排名第三）、中科院百篇优秀博士论文（2011）、中科院院长奖优秀奖（2010）等奖项。 社会兼职 科研项目 代表性论文 1) Yu Gao, Jingjing Xie, Haijun Chen, Songen Gu, Rongli Zhao, Jingwei Shao, Lee Jia*. Nanotechnology-based intelligent drug design for cancer metastasis treatment. Biotechnology Advances, 32(2014)761-777 (IF = 9.599) 2) Yu Gao, Jingwei Shao, Zhou Jiang, Songen Gu, Suhong Yu, Ke Zheng, Lee Jia*. Drug enterohepatic circulation and disposition: constituents of systems pharmacokinetics. Drug Discovery Today 19(2014)326-340. (IF = 6.551) 3) Jianzhong Chen, Jichuang Wang, Jingwei Shao, Yu Gao, Jianguo Xu, Suhong Yu, Zhenhua Liu, Lee Jia*. The unique pharmacological characteristics of Mifepristone (RU486): from terminating pregnancy to preventing cancer metastasis. Medicinal Research Reviews, DOI 10.1002/med, 2014. (IF = 9.583) 4) Haijun Chen*, Xiaobin Zhou, Yu Gao, Biyuan Zheng, Fengxiang Tang, Jiandong Huang*. Recent progress in development of new sonosensitizers for sonodynamic cancer therapy. Drug Discovery Today, 19(2014)502-509.(IF = 6.551) 5) Yusheng Lu1, Ting Yu1, Haiyan Liang1, Jichuang Wang1, Jingjing Xie1, Jingwei Shao1, Yu Gao1,Suhong Yu1, Shuming Chen2, Lie Wang2 & Lee Jia1. Nitric oxide inhibits hetero-adhesion of cancer cells to endothelial cells: restraining circulating tumor cells from initiating metastatic cascade.Sci Rep. 4(2014)4344. 6) Jian-Zhong Chena,b,1, Ji-Chuang Wanga,1, Yu Gaoa, Rong-Jie Zengb, Zhou Jianga,Ye-Wei Zhua, Jing-Wei Shaoa, Lee Jiaa,? A novel UPLC/MS/MS method for rapid determination of metapristonein rat plasma, a new cancer metastasis chemopreventive agentderived from mifepristone (RU486). Journal of Pharmaceutical and Biomedical Analysis 95 (2014) 158–163 2013年以前 1. Yu Gao1, Yu Chen1, Xiufeng Ji1, Xinyu He, Qi Yin, Zhiwen Zhang, Jianlin Shi, Yaping Li. Controlled intracellular release of doxorubicin in multidrug resistant cancer cells by tuning the shell-pore sizes of mesoporous silica nanoparticles. ACS Nano 5 (2011) 9788-9798. (IF = 10.774) 2. Yu Gao, Lingli Chen, Zhiwen Zhang, Wangwen Gu, Yaping Li. Reversal of multidrug resistance by reduction-sensitive linear cationic click polymer/iMDR1-pDNA complex nanoparticles. Biomaterials 32 (2011) 1738-1747. (IF = 7.404) 3. Qianjun He1, Yu Gao1 (co-first author), Lingxia Zhang, Zhiwen Zhang, Fang Gao, Xiufeng Ji, Yaping Li, Jianlin Shi. A pH-responsive mesoporous silica nanoparticles-based multi-drug delivery system for overcoming multi-drug resistance. Biomaterials 32 (2011) 7711-7720. (IF = 7.404) 4. Yu Gao1, Wangwen Gu1, Lingli Chen, Zhenghong Xu, Yaping Li. The role of daidzein-loaded sterically stabilized solid lipid nanoparticles in therapy for cardio-cerebrovascular diseases. Biomaterials 29 (2008) 4129-4136. (IF = 7.404) 5. Jianan Shen1, Qianjun He1, Yu Gao1 (co-first author), Jianlin Shi,Yaping Li. Mesoporous silica nanoparticles loading doxorubicin reverse multidrug resistance: performance and mechanism. Nanoscale 3 (2011) 4314-4322. (IF = 5.914) 6. Yu Gao1, Rongfu Yang1, Zhiwen Zhang, Lingli Chen, Zuyue Sun, Yaping Li. Solid lipid nanoparticles reduce systemic toxicity of docetaxel: performance and mechanism in animal. Nanotoxicology 5 (2011) 636-649. (IF = 5.758) 7. Yu Gao1, Wangwen Gu1, Lingli Chen, Zhenghong Xu, Yaping Li. A multifunctional nano device as non-viral vector for gene delivery: in vitro characteristics and transfection. Journal of Controlled Release 118 (2007) 381-388. (IF = 5.732) 8. Yu Gao, Lingli Chen, Zhiwen Zhang, Wangwen Gu, Yaping Li. Linear cationic click polymer for gene delivery: synthesis, biocompatibility, and in vitro transfection. Biomacromolecules 11 (2010) 3102-3111. (IF = 5.479) 9. Yu Gao, Zhiwen Zhang, Lingli Chen, Wangwen Gu, Yaping Li. Synthesis of 6-N,N,N-trimethyltriazole chitosan via “click chemistry” and evaluation for gene delivery. Biomacromolecules 10 (2009) 2175-2182. (IF = 5.479) 10. Yu Gao, Qi Yin, Lingli Chen, Zhiwen Zhang, Yaping Li. Linear cationic click polymers/DNA nanoparticles: in vitro structure-activity relationship and in vivo evaluation for gene delivery. Bioconjugate Chemistry 22 (2011) 1153-1161. (IF = 4.930) 11. Yu Gao1, Lingli Chen1, Wangwen Gu, Yong Xi, Liping Lin, Yaping Li. Targeted nanoassembly loaded with docetaxel improves intracellular drug delivery and efficacy in murine breast cancer model. Molecular Pharmaceutics 5 (2008) 1044-1054. (IF = 4.782) 12. Xiufeng Ji1, Yu Gao1 (co-first author), Lingli Chen, Zhiwen Zhang, Yihui Deng, Yaping Li. Nanohybrid systems of non-ionic surfactant inserting liposomes loading paclitaxel for reversal of multidrug resistance. International Journal of Pharmaceutics 422 (2012) 390-397. (IF = 3.350) 13. Yu Gao1, Pengfei Xu1, Lingli Chen, Yaping Li. Prostaglandin E1 encapsulated into lipid nanoparticles improves its anti-inflammatory effect with low side-effect. International Journal of Pharmaceutics 387 (2010) 263-271. (IF = 3.350) 14. Yu Gao, Wangwen Gu, Lingli Chen, Yaping Li. Chitosan N-betainates/DNA self-assembly nanoparticles for gene delivery: in vitro uptake and transfection efficiency. International Journal of Pharmaceutics 371 (2009) 156-162. (IF = 3.350) 15. Yu Gao, Zhenghong Xu, Chen Shangwei, Wangwen Gu, Lingli Chen,Yaping Li. Arginine-chitosan/DNA self-assemble nanoparticles for gene delivery: in vitro characteristics and transfection efficiency. International Journal of Pharmaceutics 359 (2008) 241-246. (IF = 3.350) 16. Yu Chen, Yu Gao, Hangrong Chen, Deping Zeng, Yaping Li, Yuanyi Zheng, Faqi Li, Xiufeng Ji, Xia Wang, Feng Chen, Qianjun He, Linlin Zhang, Jianlin Shi. Engineering inorganic nanoemulsions/nanoliposomes by fluoride-silica chemistry for efficient delivery/co-delivery of hydrophobic agents. Advanced Functional Materials 22 (2012) 1586-1597. (IF = 10.179) 17. Qianjun He, Yu Gao, Lingxia Zhang, Wenbo Bu, Hangrong Chen, Yaping Li, Jianlin Shi. One-pot self-assembly of mesoporous silica nanoparticle-based pH-responsive anti-cancer nano drug delivery system. Journal of Materials Chemistry 21 (2011) 15190-15192. (IF = 5.968) 18. Qi Yin, Yu Gao, Zhiweng Zhang, Pengcheng Zhang, Yaping Li. Bioreducible poly (β-amino esters)/shRNA complex nanoparticles for efficient RNA delivery. Journal of Controlled Release 151 (2011) 35-44. (IF = 5.732) 19. Yongxin Yang, Yu Gao, Lingli Chen, Yongzhuo Huang, Yaping Li. Downregulation of survivin expression and enhanced chemosensitivity of MCF-7 cells to adriamycin by PDMAE/survivin shRNA complex nanoparticles. International Journal of Pharmaceutics 405 (2011)188-195. (IF = 3.350) 20. Huihui Bu, Yu Gao, Yaping Li. Overcoming multidrug resistance (MDR) in cancer by nanotechnology. Sci. China Ser. B-Chem. 53 (2010) 2226-2232. (IF = 1.199) 21. Qianjun He, Zhiwen Zhang, Yu Gao, Jianlin Shi, Yaping Li. Intracellular localization and cytotoxicity of spherical mesoporous silica nano- and microparticles. Small 5（2009）2722-2729. (IF = 8.349) 22. Wangwen Gu, Zhenghong Xu, Yu Gao, Lingli Chen, Yaping Li. Transferrin-mediated PEGylated nanoparticles for delivery of DNA/PLL complexes. Nanotechnology 17 (2006) 4148-4155. (IF = 3.979) 23. Zhenghong Xu, Lingli Chen, Wangwen Gu, Yu Gao, Liping Lin, Zhiwen Zhang, Yong Xi, Yaping Li. The performance of docetaxel-loaded solid lipid nanoparticles targeted to hepatocellular carcinoma. Biomaterials 30 (2009) 226-232. (IF = 7.404) 24. Yongxin Yang, Zhenghong Xu, Jingui Jiang, Yu Gao, Wangwen Gu, Yaping Li. Poly(imidazole/DMAEA)phosphazene/DNA self- assembled nanoparticles for gene delivery: synthesis and in vitro transfection. Journal of Controlled Release 127 (2008) 273-279. (IF = 5.732) 25. Zhenghong Xu, Wangwen Gu, Lingli Chen, Yu Gao, Zhiwen Zhang, Yaping Li. A smart nanoassembly consisting of acid-labile vinyl ether PEG-DOPE and protamine for gene delivery: preparation and in vitro transfection. Biomacromolecules 9 (2008) 3119-3126. (IF = 5.479) 26. Yongxin Yang, Zhenghong Xu, Shangwei Chen, Yu Gao, Wangwen Gu, Lingli Chen, Yuanying Pei, Yaping Li. Histidylated cationic polyorganophosphazene/DNA self-assembled nanoparticles for gene delivery. International Journal of Pharmaceutics 353 (2008) 277-282. (IF = 3.350) 27. Pengcheng Zhang, Lingli Chen, Wangwen Gu, Zhenghong Xu, Yu Gao, Yaping Li. In vitro and in vivo evaluation of donepezil-sustained release microparticles for the treatment of Alzheimer’s disease. Biomaterial 28 (2007) 1882-1888. (IF = 7.404)
获奖情况 ☆ 2011年中国科学院百篇优秀博士论文 ☆ 2010年中国科学院院长奖优秀奖 ☆ 中科院2009-2010学年“三好学生标兵” ☆ 2009年上海药学科技一等奖（第三完成人） ☆ 中科院2008-2009学年“三好学生” ☆ 2007年度中国科学院地奥奖学金二等奖 ☆ 中科院2006-2007学年“三好学生” ☆ 2005年福州大学“优秀毕业生” |
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